Ophiobolin A kills human glioblastoma cells by inducing endoplasmic reticulum stress via disruption of thiol proteostasis

Ophiobolin A (OP-A), a fungal sesterterpene from Bipolaris oryzae, was recently shown to have anti-glioma activity. We show here that OP-A induces paraptosis-like cell death accompanied by dilation of the endoplasmic reticulum (ER) in glioma cells, and that CHOP-mediated ER stress plays a critical r...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Kim, In Young, Kwon, MiRi, Choi, Min-Koo, Lee, Dongjoo, Lee, Dong Min, Seo, Min Ji, Choi, Kyeong Sook
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739770/
https://ncbi.nlm.nih.gov/pubmed/29290985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22537
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