Doxycycline inhibits breast cancer EMT and metastasis through PAR-1/NF-κB/miR-17/E-cadherin pathway

Doxycycline displays high efficiency for cancer therapy. However, the molecular mechanism is poorly understood. In our previous study, doxycycline was found to suppress tumor progression by directly targeting proteinase-activated receptor 1 (PAR1). In this study, microRNAs were found to be involved...

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Udgivet i:Oncotarget
Main Authors: Zhong, Weilong, Chen, Shuang, Qin, Yuan, Zhang, Heng, Wang, Hongzhi, Meng, Jing, Huai, Longcong, Zhang, Qiang, Yin, Tingting, Lei, Yueyang, Han, Jingxia, He, Lingfei, Sun, Bo, Liu, Huijuan, Liu, Yanrong, Zhou, Honggang, Sun, Tao, Yang, Cheng
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739605/
https://ncbi.nlm.nih.gov/pubmed/29285218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20418
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