The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed when liver metastases already emerged. This study elucidated the impact of hepatic stromal cells on growth behavior of premalignant and malignant pancreatic ductal epithelial cells (PDECs). Liver sections of tumor-bearing KPC mice comprised...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Lenk, Lennart, Pein, Maren, Will, Olga, Gomez, Beatriz, Viol, Fabrice, Hauser, Charlotte, Egberts, Jan-Hendrik, Gundlach, Jan-Paul, Helm, Ole, Tiwari, Sanjay, Weiskirchen, Ralf, Rose-John, Stefan, Röcken, Christoph, Mikulits, Wolfgang, Wenzel, Patrick, Schneider, Günter, Saur, Dieter, Schäfer, Heiner, Sebens, Susanne
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739558/
https://ncbi.nlm.nih.gov/pubmed/29296518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1368603
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