Phosphorylation of KLC1 modifies interaction with JIP1 and abolishes the enhanced fast velocity of APP transport by kinesin-1

In neurons, amyloid β-protein precursor (APP) is transported by binding to kinesin-1, mediated by JNK-interacting protein 1b (JIP1b), which generates the enhanced fast velocity (EFV) and efficient high frequency (EHF) of APP anterograde transport. Previously, we showed that EFV requires conventional...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Chiba, Kyoko, Chien, Ko-yi, Sobu, Yuriko, Hata, Saori, Kato, Shun, Nakaya, Tadashi, Okada, Yasushi, Nairn, Angus C., Kinjo, Masataka, Taru, Hidenori, Wang, Rong, Suzuki, Toshiharu
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739300/
https://ncbi.nlm.nih.gov/pubmed/29093025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-05-0303
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