Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system

G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in eukaryotes and detect a wide array of cues in the human body. Here we describe a molecular device that couples CRISPR-dCas9 genome regulation to diverse natural and synthetic extracellular signals via...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Kipniss, Nathan H., Dingal, P. C. Dave P., Abbott, Timothy R., Gao, Yuchen, Wang, Haifeng, Dominguez, Antonia A., Labanieh, Louai, Qi, Lei S.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738360/
https://ncbi.nlm.nih.gov/pubmed/29263378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02075-1
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