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Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system
G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in eukaryotes and detect a wide array of cues in the human body. Here we describe a molecular device that couples CRISPR-dCas9 genome regulation to diverse natural and synthetic extracellular signals via...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5738360/ https://ncbi.nlm.nih.gov/pubmed/29263378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02075-1 |
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