Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer

BACKGROUND: High oxidative stress as defined by hydroxyl and peroxyl activity is often found in the stroma of human breast cancers. Oxidative stress induces stromal catabolism, which promotes cancer aggressiveness. Stromal cells exposed to oxidative stress release catabolites such as lactate, which...

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Bibliografske podrobnosti
izdano v:Semin Oncol
Main Authors: Monti, Daniel, Sotgia, Federica, Whitaker-Menezes, Diana, Tuluc, Madalina, Birbe, Ruth, Berger, Adam, Lazar, Melissa, Cotzia, Paolo, Draganova-Tacheva, Rossitza, Lin, Zhao, Domingo-Vidal, Marina, Newberg, Andrew, Lisanti, Michael P., Martinez-Outschoorn, Ubaldo
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737796/
https://ncbi.nlm.nih.gov/pubmed/29248134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.seminoncol.2017.10.001
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