N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing

N6-methyladenosine (m(6)A) is the most abundant base modification found in messenger RNAs (mRNAs). The discovery of FTO as the first m(6)A mRNA demethylase established the concept of reversible RNA modification. Here, we present a comprehensive transcriptome-wide analysis of RNA demethylation and un...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Bartosovic, Marek, Molares, Helena Covelo, Gregorova, Pavlina, Hrossova, Dominika, Kudla, Grzegorz, Vanacova, Stepanka
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
Assuntos:
RNA and RNA-protein complexes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737695/
https://ncbi.nlm.nih.gov/pubmed/28977517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx778
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