Analysis of primary microRNA loci from nascent transcriptomes reveals regulatory domains governed by chromatin architecture

Changes in mature microRNA (miRNA) levels that occur downstream of signaling cascades play an important role during human development and disease. However, the regulation of primary microRNA (pri-miRNA) genes remains to be dissected in detail. To address this, we followed a data-driven approach and...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Bouvy-Liivrand, Maria, Hernández de Sande, Ana, Pölönen, Petri, Mehtonen, Juha, Vuorenmaa, Tapio, Niskanen, Henri, Sinkkonen, Lasse, Kaikkonen, Minna Unelma, Heinäniemi, Merja
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Computational Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737680/
https://ncbi.nlm.nih.gov/pubmed/28973462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx680
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