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Transcription-coupled genetic instability marks acute lymphoblastic leukemia structural variation hotspots
Progression of malignancy to overt disease requires multiple genetic hits. Activation-induced deaminase (AID) can drive lymphomagenesis by generating off-target DNA breaks at loci that harbor highly active enhancers and display convergent transcription. The first active transcriptional profiles from...
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Publicado no: | eLife |
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Main Authors: | , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
eLife Sciences Publications, Ltd
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4951197/ https://ncbi.nlm.nih.gov/pubmed/27431763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13087 |
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