Transcription-coupled genetic instability marks acute lymphoblastic leukemia structural variation hotspots

Progression of malignancy to overt disease requires multiple genetic hits. Activation-induced deaminase (AID) can drive lymphomagenesis by generating off-target DNA breaks at loci that harbor highly active enhancers and display convergent transcription. The first active transcriptional profiles from...

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Dettagli Bibliografici
Pubblicato in:eLife
Autori principali: Heinäniemi, Merja, Vuorenmaa, Tapio, Teppo, Susanna, Kaikkonen, Minna U, Bouvy-Liivrand, Maria, Mehtonen, Juha, Niskanen, Henri, Zachariadis, Vasilios, Laukkanen, Saara, Liuksiala, Thomas, Teittinen, Kaisa, Lohi, Olli
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2016
Soggetti:
Genes and Chromosomes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951197/
https://ncbi.nlm.nih.gov/pubmed/27431763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13087
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