Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities

BACKGROUND: Tight regulatory loops orchestrate commitment to B cell fate within bone marrow. Genetic lesions in this gene regulatory network underlie the emergence of the most common childhood cancer, acute lymphoblastic leukemia (ALL). The initial genetic hits, including the common translocation th...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Mehtonen, Juha, Teppo, Susanna, Lahnalampi, Mari, Kokko, Aleksi, Kaukonen, Riina, Oksa, Laura, Bouvy-Liivrand, Maria, Malyukova, Alena, Mäkinen, Artturi, Laukkanen, Saara, Mäkinen, Petri I., Rounioja, Samuli, Ruusuvuori, Pekka, Sangfelt, Olle, Lund, Riikka, Lönnberg, Tapio, Lohi, Olli, Heinäniemi, Merja
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7679990/
https://ncbi.nlm.nih.gov/pubmed/33218352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-020-00799-2
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