Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates

Covalent attachment of a synthetic triantennary N-acetylagalactosamine (GalNAc) ligand to chemically modified siRNA has enabled asialoglycoprotein (ASGPR)-mediated targeted delivery of therapeutically active siRNAs to hepatocytes in vivo. This approach has become transformative for the delivery of R...

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書誌詳細
出版年:Nucleic Acids Res
主要な著者: Nair, Jayaprakash K., Attarwala, Husain, Sehgal, Alfica, Wang, Qianfan, Aluri, Krishna, Zhang, Xuemei, Gao, Minggeng, Liu, Ju, Indrakanti, Ramesh, Schofield, Sally, Kretschmer, Philip, Brown, Christopher R., Gupta, Swati, Willoughby, Jennifer L.S., Boshar, Julie A., Jadhav, Vasant, Charisse, Klaus, Zimmermann, Tracy, Fitzgerald, Kevin, Manoharan, Muthiah, Rajeev, Kallanthottathil G., Akinc, Akin, Hutabarat, Renta, Maier, Martin A.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2017
主題:
Chemical Biology and Nucleic Acid Chemistry
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737438/
https://ncbi.nlm.nih.gov/pubmed/28981809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx818
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