A ‘new lease of life’: FnCpf1 possesses DNA cleavage activity for genome editing in human cells

Cpf1 nucleases were recently reported to be highly specific and programmable nucleases with efficiencies comparable to those of SpCas9. AsCpf1 and LbCpf1 require a single crRNA and recognize a 5′-TTTN-3′ protospacer adjacent motif (PAM) at the 5′ end of the protospacer for genome editing. For widesp...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Tu, Mengjun, Lin, Li, Cheng, Yilu, He, Xiubin, Sun, Huihui, Xie, Haihua, Fu, Junhao, Liu, Changbao, Li, Jin, Chen, Ding, Xi, Haitao, Xue, Dongyu, Liu, Qi, Zhao, Junzhao, Gao, Caixia, Song, Zongming, Qu, Jia, Gu, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737432/
https://ncbi.nlm.nih.gov/pubmed/28977650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx783
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