Engineering the Direct Repeat Sequence of crRNA for Optimization of FnCpf1-Mediated Genome Editing in Human Cells

FnCpf1-mediated genome-editing technologies have enabled a broad range of research and medical applications. Recently, we reported that FnCpf1 possesses activity in human cells and recognizes a more compatible PAM (protospacer adjacent motif, 5′-KYTV-3′), compared with the other two commonly used Cp...

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Gepubliceerd in:Mol Ther
Hoofdauteurs: Lin, Li, He, Xiubin, Zhao, Tianyuan, Gu, Lingkai, Liu, Yeqing, Liu, Xiaoyu, Liu, Hongyan, Yang, Fayu, Tu, Mengjun, Tang, Lianchao, Ge, Xianglian, Liu, Changbao, Zhao, Junzhao, Song, Zongming, Qu, Jia, Gu, Feng
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Gene & Cell Therapy 2018
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224799/
https://ncbi.nlm.nih.gov/pubmed/30274789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.08.021
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