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Unraveling the Role of RNA Mediated Toxicity of C9orf72 Repeats in C9-FTD/ALS
The most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is intronic hexanucleotide (G4C2) repeat expansions (HRE) in the C9orf72 gene. The non-exclusive pathogenic mechanisms by which C9orf72 repeat expansions contribute to these neurological disorder...
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| Publicado en: | Front Neurosci |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Frontiers Media S.A.
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5736982/ https://ncbi.nlm.nih.gov/pubmed/29326544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2017.00711 |
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