Native or Proteolytically Activated NanI Sialidase Enhances the Binding and Cytotoxic Activity of Clostridium perfringens Enterotoxin and Beta Toxin

Many Clostridium perfringens strains produce NanI as their major sialidase. Previous studies showed that NanI could potentiate C. perfringens epsilon toxin cytotoxicity by enhancing the binding of this toxin to host cells. The present study first determined that NanI exerts similar cytotoxicity-enha...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Theoret, James R., Li, Jihong, Navarro, Mauricio A., Garcia, Jorge P., Uzal, Francisco A., McClane, Bruce A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736825/
https://ncbi.nlm.nih.gov/pubmed/29038129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00730-17
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