Native or Proteolytically Activated NanI Sialidase Enhances the Binding and Cytotoxic Activity of Clostridium perfringens Enterotoxin and Beta Toxin

Many Clostridium perfringens strains produce NanI as their major sialidase. Previous studies showed that NanI could potentiate C. perfringens epsilon toxin cytotoxicity by enhancing the binding of this toxin to host cells. The present study first determined that NanI exerts similar cytotoxicity-enha...

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Udgivet i:Infect Immun
Main Authors: Theoret, James R., Li, Jihong, Navarro, Mauricio A., Garcia, Jorge P., Uzal, Francisco A., McClane, Bruce A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Molecular Pathogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736825/
https://ncbi.nlm.nih.gov/pubmed/29038129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00730-17
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