Native or Proteolytically Activated NanI Sialidase Enhances the Binding and Cytotoxic Activity of Clostridium perfringens Enterotoxin and Beta Toxin

Many Clostridium perfringens strains produce NanI as their major sialidase. Previous studies showed that NanI could potentiate C. perfringens epsilon toxin cytotoxicity by enhancing the binding of this toxin to host cells. The present study first determined that NanI exerts similar cytotoxicity-enha...

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Dades bibliogràfiques
Publicat a:Infect Immun
Autors principals: Theoret, James R., Li, Jihong, Navarro, Mauricio A., Garcia, Jorge P., Uzal, Francisco A., McClane, Bruce A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Molecular Pathogenesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736825/
https://ncbi.nlm.nih.gov/pubmed/29038129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00730-17
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