Diblock Copolymer Hydrophobicity Facilitates Efficient Gene Silencing and Cytocompatible Nanoparticle-Mediated siRNA Delivery to Musculoskeletal Cell Types

pH-responsive diblock copolymers provide tailorable nanoparticle (NP) architecture and chemistry critical for siRNA delivery. Here, diblock polymers varying in first (corona) and second (core) block molecular weight (M(n)), corona/core ratio, and core hydrophobicity (%BMA) were synthesized to determ...

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Publicado en:Biomacromolecules
Autores principales: Malcolm, Dominic W., Freeberg, Margaret A. T., Wang, Yuchen, Sims, Kenneth R., Awad, Hani A., Benoit, Danielle S. W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736382/
https://ncbi.nlm.nih.gov/pubmed/28960967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biomac.7b01349
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