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Controlled and sustained delivery of siRNA/NPs from hydrogels expedites bone fracture healing

Despite great potential, delivery remains as the most significant barrier to the widespread use of siRNA therapeutics. siRNA has delivery limitations due to susceptibility to RNase degradation, low cellular uptake, and poor tissue-specific localization. Here, we report the development of a hybrid na...

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Publicat a:Biomaterials
Autors principals: Wang, Yuchen, Malcolm, Dominic W., Benoit, Danielle S.W.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599180/
https://ncbi.nlm.nih.gov/pubmed/28601703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2017.06.001
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