Influence of an immunodominant herpes simplex virus type 1 CD8(+) T cell epitope on the target hierarchy and function of subdominant CD8(+) T cells

Herpes simplex virus type 1 (HSV-1) latency in sensory ganglia such as trigeminal ganglia (TG) is associated with a persistent immune infiltrate that includes effector memory CD8(+) T cells that can influence HSV-1 reactivation. In C57BL/6 mice, HSV-1 induces a highly skewed CD8(+) T cell repertoire...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Treat, Benjamin R., Bidula, Sarah M., Ramachandran, Srividya, St Leger, Anthony J., Hendricks, Robert L., Kinchington, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736228/
https://ncbi.nlm.nih.gov/pubmed/29206240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006732
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