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Herpes Simplex Virus 1-Specific CD8(+) T Cell Priming and Latent Ganglionic Retention Are Shaped by Viral Epitope Promoter Kinetics

Reactivation of herpes simplex virus 1 (HSV-1) from neurons in sensory ganglia such as the trigeminal ganglia (TG) is influenced by virus-specific CD8(+) T cells that infiltrate the ganglia at the onset of latency and contract to a stable activated tissue-resident memory population. In C57BL/6 mice,...

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Udgivet i:J Virol
Main Authors: Treat, Benjamin R., Bidula, Sarah M., St. Leger, Anthony J., Hendricks, Robert L., Kinchington, Paul R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022356/
https://ncbi.nlm.nih.gov/pubmed/31826989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01193-19
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