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A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats

Neuroinflammation is potentiated by early degeneration of the locus coeruleus noradrenergic pathway (LC-NE) commonly seen in aging-related neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. In animal models, lipopolysaccharide (LPS) induces strong peripheral immune respo...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Bharani, Krishna L., Derex, Rebecca, Granholm, Ann-Charlotte, Ledreux, Aurélie
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736222/
https://ncbi.nlm.nih.gov/pubmed/29261743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189821
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