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Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
Misfolded endoplasmic reticulum (ER) proteins are retro-translocated through the membrane into the cytosol, where they are poly-ubiquitinated, extracted from the ER membrane, and degraded by the proteasome 1–4, a pathway termed ER-associated protein degradation (ERAD). Proteins with misfolded domain...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5736104/ https://ncbi.nlm.nih.gov/pubmed/28682307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23314 |
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