Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3

Misfolded endoplasmic reticulum (ER) proteins are retro-translocated through the membrane into the cytosol, where they are poly-ubiquitinated, extracted from the ER membrane, and degraded by the proteasome 1–4, a pathway termed ER-associated protein degradation (ERAD). Proteins with misfolded domain...

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Publicat a:Nature
Autors principals: Schoebel, Stefan, Mi, Wei, Stein, Alexander, Ovchinnikov, Sergey, Pavlovicz, Ryan, DiMaio, Frank, Baker, David, Chambers, Melissa G., Su, Huayou, Li, Dongsheng, Rapoport, Tom A., Liao, Maofu
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736104/
https://ncbi.nlm.nih.gov/pubmed/28682307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23314
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