Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases

β-Lactamases (BLs) able to hydrolyze β-lactam antibiotics and more importantly the last resort carbapenems, represent a major mechanism of resistance in Gram-negative bacteria showing multi-drug or extensively drug resistant phenotypes. The early detection of BLs responsible of resistant infections...

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Udgivet i:Sci Rep
Main Authors: Santucci, Matteo, Spyrakis, Francesca, Cross, Simon, Quotadamo, Antonio, Farina, Davide, Tondi, Donatella, De Luca, Filomena, Docquier, Jean-Denis, Prieto, Ana Isabel, Ibacache, Claudia, Blázquez, Jesús, Venturelli, Alberto, Cruciani, Gabriele, Costi, Maria Paola
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5735191/
https://ncbi.nlm.nih.gov/pubmed/29255163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17399-7
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