Src family kinase tyrosine phosphorylates Toll-like receptor 4 to dissociate MyD88 and Mal/Tirap, suppressing LPS-induced inflammatory responses

Src family kinases (SFKs) are a family of protein tyrosine kinases containing nine members: Src, Lyn, Fgr, Hck, Lck, Fyn, Blk, Yes, and Ylk. Although SFK activation is a major immediate signaling event in LPS/Toll-like receptor 4 (TLR4) signaling, its precise role has remained elusive due to various...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biochem Pharmacol
Hauptverfasser: Mitchell, Jonathon, Kim, Su Jin, Seelmann, Alexandra, Veit, Brendan, Shepard, Brooke, Im, Eunok, Rhee, Sang Hoon
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733702/
https://ncbi.nlm.nih.gov/pubmed/29175418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2017.11.015
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge