Src family kinase tyrosine phosphorylates Toll-like receptor 4 to dissociate MyD88 and Mal/Tirap, suppressing LPS-induced inflammatory responses

Src family kinases (SFKs) are a family of protein tyrosine kinases containing nine members: Src, Lyn, Fgr, Hck, Lck, Fyn, Blk, Yes, and Ylk. Although SFK activation is a major immediate signaling event in LPS/Toll-like receptor 4 (TLR4) signaling, its precise role has remained elusive due to various...

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Bibliografiske detaljer
Udgivet i:	Biochem Pharmacol
Main Authors:	Mitchell, Jonathon, Kim, Su Jin, Seelmann, Alexandra, Veit, Brendan, Shepard, Brooke, Im, Eunok, Rhee, Sang Hoon
Format:	Artigo
Sprog:	Inglês
Udgivet:	2017
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5733702/ https://ncbi.nlm.nih.gov/pubmed/29175418 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2017.11.015
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Src family kinase tyrosine phosphorylates Toll-like receptor 4 to dissociate MyD88 and Mal/Tirap, suppressing LPS-induced inflammatory responses

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