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Conformational Dynamics of the Human Islet Amyloid Polypeptide in a Membrane Environment – towards the Aggregation Prone Form
Human islet amyloid polypeptide (hIAPP) is a 37-residue peptide hormone, which upon misfolding changes from the physiologically active monomer into pathological amyloid fibril aggregates in the pancreas of type 2 diabetes mellitus patients. During this process, the insulin-producing pancreatic β-cel...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Biochemistry |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5733697/ https://ncbi.nlm.nih.gov/pubmed/26953503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00507 |
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