The Brucella effector protein TcpB induces degradation of inflammatory caspases and thereby subverts non-canonical inflammasome activation in macrophages

The inflammasome contains intracellular receptors that recognize various pathogen-associated molecular patterns and play crucial roles in innate immune responses to invading pathogens. Non-canonical inflammasome activation is mediated by caspase-4/11, which recognizes intracellular LPS and promotes...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Jakka, Padmaja, Namani, Swapna, Murugan, Subathra, Rai, Nivedita, Radhakrishnan, Girish
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733597/
https://ncbi.nlm.nih.gov/pubmed/29061850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.815878
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