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The neurosteroid pregnenolone promotes degradation of key proteins in the innate immune signaling to suppress inflammation
Pregnenolone is a steroid hormone precursor that is synthesized in various steroidogenic tissues, in the brain, and in lymphocytes. In addition to serving as the precursor for other steroid hormones, pregnenolone exerts its own effect as an anti-inflammatory molecule to maintain immune homeostasis i...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6433066/ https://ncbi.nlm.nih.gov/pubmed/30647133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005543 |
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