Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone.

Oligodendrocyte mitochondria from 21-day-old Sprague-Dawley male rats were incubated with 100 nM [3H]cholesterol. It yielded [3H]pregnenolone at a rate of 2.5 +/- 0.7 and 5-[3H]pregnene-3 beta, 20 alpha-diol at a rate of 2.5 +/- 1.1 pmol per mg of protein per hr. Cultures of glial cells from 19- to...

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Autors principals: Hu, Z Y, Bourreau, E, Jung-Testas, I, Robel, P, Baulieu, E E
Format: Artigo
Idioma:Inglês
Publicat: 1987
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC299512/
https://ncbi.nlm.nih.gov/pubmed/3479785
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