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Neurosteroids: Deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus

Pregnenolone sulfate (PREG S) is synthesized in the nervous system and is a major neurosteroid in the rat brain. Its concentrations were measured in the hippocampus and other brain areas of single adult and aged (22–24 month-old) male Sprague–Dawley rats. Significantly lower levels were found in age...

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Detalhes bibliográficos
Main Authors: Vallée, Monique, Mayo, Willy, Darnaudéry, Muriel, Corpéchot, Colette, Young, Jacques, Koehl, Muriel, Le Moal, Michel, Baulieu, Etienne-Emile, Robel, Paul, Simon, Hervé
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1997
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC25129/
https://ncbi.nlm.nih.gov/pubmed/9405705
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