Neurosteroids: Deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus

Pregnenolone sulfate (PREG S) is synthesized in the nervous system and is a major neurosteroid in the rat brain. Its concentrations were measured in the hippocampus and other brain areas of single adult and aged (22–24 month-old) male Sprague–Dawley rats. Significantly lower levels were found in age...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Vallée, Monique, Mayo, Willy, Darnaudéry, Muriel, Corpéchot, Colette, Young, Jacques, Koehl, Muriel, Le Moal, Michel, Baulieu, Etienne-Emile, Robel, Paul, Simon, Hervé
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25129/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9405705/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.26.14865
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