Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone.

Oligodendrocyte mitochondria from 21-day-old Sprague-Dawley male rats were incubated with 100 nM [3H]cholesterol. It yielded [3H]pregnenolone at a rate of 2.5 +/- 0.7 and 5-[3H]pregnene-3 beta, 20 alpha-diol at a rate of 2.5 +/- 1.1 pmol per mg of protein per hr. Cultures of glial cells from 19- to...

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izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Hu, Z Y, Bourreau, E, Jung-Testas, I, Robel, P, Baulieu, E E
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1987
Teme:	Research Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299512/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3479785/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.23.8215
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