Mechanism of Bacterial Interference with TLR4 Signaling by Brucella Toll/Interleukin-1 Receptor Domain-containing Protein TcpB

Upon activation of Toll-like receptors (TLRs), cytoplasmic Toll/interleukin-1 receptor (TIR) domains of the receptors undergo homo- or heterodimerization. This in turn leads to the recruitment of adaptor proteins, activation of transcription factors, and the secretion of pro-inflammatory cytokines....

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Detalhes bibliográficos
Main Authors: Alaidarous, Mohammed, Ve, Thomas, Casey, Lachlan W., Valkov, Eugene, Ericsson, Daniel J., Ullah, M. Obayed, Schembri, Mark A., Mansell, Ashley, Sweet, Matthew J., Kobe, Bostjan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887194/
https://ncbi.nlm.nih.gov/pubmed/24265315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.523274
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