Crystallization and X-ray diffraction analysis of the N-terminal domain of the Toll-like receptor signalling adaptor protein TRIF/TICAM-1

As part of the mammalian innate immune response, Toll-like receptors 3 and 4 can signal via the adaptor protein TRIF/TICAM-1 to elicit the production of type-I interferons and cytokines. Recent studies have suggested an auto-inhibitory role for the N-terminal domain (NTD) of TRIF. This domain has no...

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Bibliographic Details
Main Authors: Ullah, M. Obayed, Ve, Thomas, Dkhar, Jameris, Alaidarous, Mohammed, Ericsson, Daniel J., Sweet, Matthew J., Mansell, Ashley, Kobe, Bostjan
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2013
Subjects:
Crystallization Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702321/
https://ncbi.nlm.nih.gov/pubmed/23832204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S174430911301419X
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