Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence

Expression of the transcription factors OCT4, SOX2, KLF4, and cMYC (OSKM) reprograms somatic cells into induced pluripotent stem cells (iPSCs). Reprogramming is a slow and inefficient process, suggesting the presence of safeguarding mechanisms that counteract cell fate conversion. One such mechanism...

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Vydáno v:Genes Dev
Hlavní autoři: Aarts, Marieke, Georgilis, Athena, Beniazza, Meryam, Beolchi, Patrizia, Banito, Ana, Carroll, Thomas, Kulisic, Marizela, Kaemena, Daniel F., Dharmalingam, Gopuraja, Martin, Nadine, Reik, Wolf, Zuber, Johannes, Kaji, Keisuke, Chandra, Tamir, Gil, Jesús
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733499/
https://ncbi.nlm.nih.gov/pubmed/29138277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.297796.117
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