A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2

The generation of induced pluripotent stem cells (iPSCs) from differentiated cells following forced expression of OCT4, KLF4, SOX2, and C-MYC (OKSM) is slow and inefficient, suggesting that transcription factors have to overcome somatic barriers that resist cell fate change. Here, we performed an un...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Borkent, Marti, Bennett, Brian D., Lackford, Brad, Bar-Nur, Ori, Brumbaugh, Justin, Wang, Li, Du, Ying, Fargo, David C., Apostolou, Effie, Cheloufi, Sihem, Maherali, Nimet, Elledge, Stephen J., Hu, Guang, Hochedlinger, Konrad
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939549/
https://ncbi.nlm.nih.gov/pubmed/26947976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.02.004
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