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Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

The overexpression of defined transcription factors in somatic cells results in their reprogramming into induced pluripotent stem (iPS) cells(1–3). The extremely low efficiency and slow kinetics of in vitro reprogramming suggest that additional rare events are required to generate iPS cells. The nat...

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Hlavní autoři: Utikal, Jochen, Polo, Jose M., Stadtfeld, Matthias, Maherali, Nimet, Kulalert, Warakorn, Walsh, Ryan M., Khalil, Adam, Rheinwald, James G., Hochedlinger, Konrad
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987892/
https://ncbi.nlm.nih.gov/pubmed/19668190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08285
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