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Differentiation stage determines reprogramming potential of hematopoietic cells into iPS cells
The reprogramming of somatic cells into induced pluripotent stem (iPS) cells upon overexpression of the transcription factors Oct4, Sox2, Klf4 and cMyc is extremely inefficient. It has been assumed that the somatic differentiation state provides a barrier for efficient reprogramming; however, direct...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3987895/ https://ncbi.nlm.nih.gov/pubmed/19668214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.428 |
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