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Novel Polyamine–Naphthalene Diimide Conjugates Targeting Histone Deacetylases and DNA for Cancer Phenotype Reprogramming

[Image: see text] A series of hybrid compounds was designed to target histone deacetylases and ds-/G-quadruplex DNAs by merging structural features deriving from Scriptaid and compound 1. Compound 6 binds different DNA arrangements, inhibits HDACs both in vitro and in cells, and is able to induce a...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Pasini, Alice, Marchetti, Chiara, Sissi, Claudia, Cortesi, Marilisa, Giordano, Emanuele, Minarini, Anna, Milelli, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733267/
https://ncbi.nlm.nih.gov/pubmed/29259737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00289
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