Magnetic resonance imaging of RRx-001 pharmacodynamics in preclinical tumors

RRx-001 is an anticancer agent that subjects cancer cells to reactive oxygen/nitrogen species (ROS/RNS) and acts as an epigenetic modifier. We have used a thiol-bearing MRI contrast agent, Gd-LC7-SH, to investigate the pharmacodynamics of RRx-001 in CHP-100 Ewing's Sarcoma, HT-29 colorectal car...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Raghunand, Natarajan, Scicinski, Jan, Guntle, Gerald P., Jagadish, Bhumasamudram, Mash, Eugene A., Bruckheimer, Elizabeth, Oronsky, Bryan, Korn, Ronald L.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Clinical Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731976/
https://ncbi.nlm.nih.gov/pubmed/29254266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18455
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