Tumor Xenograft Response to Redox-Active Therapies Assessed by Magnetic Resonance Imaging Using a Thiol-Bearing DOTA Complex of Gadolinium

Gd-LC6-SH is a thiol-bearing DOTA complex of gadolinium designed to bind plasma albumin at the conserved Cys(34) site. The binding of Gd-LC6-SH shows sensitivity to the presence of competing thiols. We hypothesized that Gd-LC6-SH could provide magnetic resonance imaging (MRI) enhancement that is sen...

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Main Authors: Guntle, Gerald P, Jagadish, Bhumasamudram, Mash, Eugene A, Powis, Garth, Dorr, Robert T, Raghunand, Natarajan
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384273/
https://ncbi.nlm.nih.gov/pubmed/22741038
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