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Redox-Sensitive Contrast Agents for MRI Based on Reversible Binding of Thiols to Serum Albumin

DOTA-based complexes of gadolinium bearing a thiol moiety on a propyl or hexyl arm were synthesized. It was hypothesized that these complexes would form reversible covalent linkages with human serum albumin (HSA) which contains a reactive thiol at cysteine-34. The binding constant of the hexyl compl...

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Detalhes bibliográficos
Main Authors: Raghunand, Natarajan, Jagadish, Bhumasamudram, Trouard, Theodore P., Galons, Jean-Philippe, Gillies, Robert J., Mash, Eugene A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1808246/
https://ncbi.nlm.nih.gov/pubmed/16700014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrm.20904
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