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Redox-Sensitive Contrast Agents for MRI Based on Reversible Binding of Thiols to Serum Albumin
DOTA-based complexes of gadolinium bearing a thiol moiety on a propyl or hexyl arm were synthesized. It was hypothesized that these complexes would form reversible covalent linkages with human serum albumin (HSA) which contains a reactive thiol at cysteine-34. The binding constant of the hexyl compl...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1808246/ https://ncbi.nlm.nih.gov/pubmed/16700014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrm.20904 |
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