Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis

Mutations in DNA repair pathways are frequent in human cancers. Hence, gaining insights into the interaction of DNA repair genes is key to development of novel tumor-specific treatment strategies. In this study, we tested the functional relationship in development and oncogenesis between the homolog...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Tanori, Mirella, Casciati, Arianna, Berardinelli, Francesco, Leonardi, Simona, Pasquali, Emanuela, Antonelli, Francesca, Tanno, Barbara, Giardullo, Paola, Pannicelli, Alessandro, Babini, Gabriele, De Stefano, Ilaria, Sgura, Antonella, Mancuso, Mariateresa, Saran, Anna, Pazzaglia, Simonetta
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731848/
https://ncbi.nlm.nih.gov/pubmed/29254138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10479
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