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Developmental and oncogenic effects of Insulin-like Growth Factor-I in Ptc1(+/- )mouse cerebellum

BACKGROUND: Medulloblastoma is amongst the most common malignant brain tumors in childhood, arising from neoplastic transformation of granule neuron precursors (GNPs) of the cerebellum via deregulation of pathways involved in cerebellar development. Deregulation of the Sonic hedgehog/Patched1 (Shh/P...

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Detalhes bibliográficos
Main Authors: Tanori, Mirella, Santone, Melissa, Mancuso, Mariateresa, Pasquali, Emanuela, Leonardi, Simona, Di Majo, Vincenzo, Rebessi, Simonetta, Saran, Anna, Pazzaglia, Simonetta
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846887/
https://ncbi.nlm.nih.gov/pubmed/20214787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-53
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