Nanog-driven cell-reprogramming and self-renewal maintenance in Ptch1(+/−) granule cell precursors after radiation injury

Medulloblastoma (MB) is the most common pediatric brain tumor, comprising four distinct molecular variants, one of which characterized by activation of the Sonic Hedgehog (SHH) pathway, driving 25–30% of sporadic MB. SHH-dependent MBs arise from granule cell precursors (GCPs), are fatal in 40–70% of...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tanno, Barbara, Leonardi, Simona, Babini, Gabriele, Giardullo, Paola, De Stefano, Ilaria, Pasquali, Emanuela, Saran, Anna, Mancuso, Mariateresa
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660207/
https://ncbi.nlm.nih.gov/pubmed/29079783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14506-6
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