SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia

Mutations in SETD2, encoding the histone 3 lysine 36 trimethyltransferase, are enriched in relapsed acute lymphoblastic leukemia and MLL-rearranged acute leukemia. We investigated the impact of SETD2 mutations on chemotherapy sensitivity in isogenic leukemia cell lines and in murine leukemia generat...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Mar, Brenton G., Chu, S. Haihua, Kahn, Josephine D., Krivtsov, Andrei V., Koche, Richard, Castellano, Cecilia A., Kotlier, Jacob L., Zon, Rebecca L., McConkey, Marie E., Chabon, Jonathan, Chappell, Ryan, Grauman, Peter V., Hsieh, James J., Armstrong, Scott A., Ebert, Benjamin L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731084/
https://ncbi.nlm.nih.gov/pubmed/29018079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-03-775569
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